A new category of psychotropic drugs:
neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E).
Horrobin
DF.
Laxdale Ltd., Kings Park House, Laurelhill Business Park, Stirling, FK7
9JQ Scotland. agreen@laxdale.co.uk
New treatments for psychiatric disorders are urgently required. Recent
reviews show that there have been no improvements in efficacy of drugs
for either affective disorders or schizophrenia since the first compounds
were introduced over 40 years ago. Neuroactive lipids represent an entirely
novel class of psychotropic compounds. Ethyl eicosapentaenoate is the
first example of this group. Placebo-controlled studies have found it
to be effective in depression, in treatment-unresponsive schizophrenia
and in tardive dyskinesia. It is extremely well tolerated with none of
the usual side-effects of either antidepressants or neuroleptics. It probably
works by modulating postreceptor signal transduction processes.
PMID: 12458967 [PubMed - indexed for MEDLINE]
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