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REFERENCES

1. [No authors listed]. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet. 1999;354:447–455.

2. A. Gaby. B6-The Natural Healer. New Canaan: Keats: 1984.

3. Access Integrative Medicine, Integrative Medicine Communications, 2000

4. Adam O, Beringer C, Kless T, et al. Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. Rheumatol Int. 2003;23:27–36.

5. Adams PB, Lawson S, Sanigorski A, Sinclair AJ. Arachidonic acid to eicosapentanoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996; 31: S157-S161.

6. Adams WK Keirer SW and Badia-Elder N. Tryptophan deficiency and alcohol consumption in rats as a model for disadvantaged human populations: a preliminary study. Medical Anthropology. 1995;16(2):175-91.

7. Agren JJ, Hanninen O, Julkunen A, et al. Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. Eur J Clin Nutr. 1996;50:765-771.

8. Ahveninen J, Kahkonen S, Pennanen S, et al. Tryptophan depletion effects on EEG and MEG responses suggest serotonergic modulation of auditory involuntary attention in humans. NeuroImage 2002;16:1052-61.

9. Al MD, et al. Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. Br J Nutr 1995;74:55-68.

10. Al MD, van Houwelingen AC, Kester AD, et al. Maternal essential fatty acid patterns during normal pregnancy and their relationship to neonatal essential fatty acid status. Br J Nutr 1995;74(1):55-68.

11. Alino, J. J., J. L. Gutierrez and M. L. Iglesias (1976). "5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study." Int Pharmacopsychiatry 11(1): 8-15.

12. Almallah YZ, El-Tahir A, Heys SD, et al. Distal procto-colitis and n-3 polyunsaturated fatty acids: the mechanism(s) of natural cytotoxicity inhibition. Eur J Clin Invest. 2000;30:58–65.

13. Angerer P, Stork S, Kothny W, et al. Effect of marine omega-3 fatty acids on peripheral atherosclerosis in patients with coronary artery disease—a randomised 2 year intervention trial [abstract]. Eur Heart J. 2001;22(suppl):162.

14. Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr. 1977;224:175–186.

15. Anon. Study links depression, heart disease. Reuters Health report, Chicago, Feb. 10, 2004.

16. Appel LJ, Miller ER III, Seidler AJ, et al. Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med. 1993;153:1429–1438.

17. Arm J. The effects of dietary supplementation with fish oil on asthmatic responses to antigen. J Allergy Clin Immunol. 1988;81:183.

18. Arm JP, Thien FC, Lee TH. Leukotrienes, fish-oil, and asthma. Allergy Proc. 1994;15:129–134.

19. Arvindakshan M, Ghate M, Ranjekar PK, et al. Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr Res 2003;62(3):195-204.

20. Ascherio A, Rimm EB, Stampfer MJ, et al. Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. N Engl J Med. 1995;332:977–982.

21. Aslan A, Triadafilopoulos G. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol. 1992;87:432–437.

22. Attele AS, Xie JT, Yuan CS. Treatment of insomnia: an alternative approach.Altern Med Rev. 2000;5(3):249-259.

23. Auffranc JC, Berbis P, Fabre JF, et al. Sclerodermiform and poikilodermal syndrome observed during treatment with carbidopa and 5-hydroxytryptophan [translated from French]. Ann Dermatol Venereol. 1985;112:691–692

24. Balch P, Balch J, Prescription For Nutritional Healing. 2000; Penguin Putnam Inc. New York, NY

25. Barber MD. Cancer cachexia and its treatment with fish-oil-enriched nutritional supplementation. Nutrition. 2001;17:751–755.

26. Barberger-Gateau P, Letenneur L, Deschamps V, et al. Fish, meat, and risk of dementia: cohort study. BMJ 2002;325(7370):932-3.

27. Barlet P, Pailard P. Etude clinique du 5-hydroxytryptophane dans les etats depressifs du troisieme age. Cah Med Lyon 1973;50:1985-1901. [Article in French]

28. Bassey EJ, Littlewood JJ, Rothwell MC, et al. Lack of effect of supplementation with essential fatty acids on bone mineral density in healthy pre- and postmenopausal women: two randomized controlled trials of EfacalŴ v. calcium alone. Br J Nutr. 2000;83:629–635.

29. Bates D. Dietary lipids and multiple sclerosis. Ups J Med Sci Suppl. 1990;48:173–187.

30. Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990;82:209–216.

31. Beck-Friis J, von Rosen D, Kjellman BF, Ljunggren JG, Wetterberg L. Melatonin in relation to body measures, sex, age season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology. 1998;9:261-77

32. Belluzzi A, Brignola C, Campieri M, et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med. 1996;334:1557–1560.

33. Belongia EA, Hedberg CW, Gleich GJ, et al. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. N Engl J Med. 1990;323:357–365.

34. Benkelfat C. Ellenbogen MA and others. Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psych. 1994;51(9):687-97.

35. Bhatara VS, Magnus RD, Paul KL, et al. Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechansims. Ann Pharmacother. 1998;32(4):432-436.

36. Billman GE, Hallaq H, Leaf A. Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids. Proc Natl Acad Sci U S A. 1994;91:4427–4430.

37. Birdsall TC, 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev 1998 Aug;3(4):271-80.

38. Bittiner SB, Cartwright I, Tucker WFG, et al. A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. Lancet. 1988;1:378–380.

39. Blommers J, De Lange-De Klerk ES, Kuik DJ, et al. Evening primrose oil and fish oil for severe chronic mastalgia: A randomized, double-blind, controlled trial. Am J Obstet Gynecol. 2002;187:1389–1394.

40. Bodner RA, et.al., Serotonin syndrome. Neurol. 1995;45(2):219-223.

41. Bono G, Criscuoli M, Martignoni E, et al. Serotonin precursors in migraine prophylaxis. Adv Neurol. 1982;33:357–363.

42. Bosker et al. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 34-501-8 (1995)

43. Bourin M, Baker GB, Bradwejn J. Neurobiology of panic disorder. J Psychosom Res 1998;44(1):163-80.

44. Bourre JM, Bonneil M, Clement M, Dumont O, et al. Function of dietary polyunsaturated fatty acids in the nervous system. Prostaglandins Leukot Essent Fatty Acids 1993; 48: 5-15.

45. Brambilla F, Maggioni M. Blood levels of cytokines in elderly patients with major depressive disorder. Acta Psychiatr Scand 1998; 97: 309-13.

46. Bratman S, Kroll D, The Natural Pharmacist: Natural Health Bible. 2000; Prima Publishing, USA

47. Bressa, G.M., 'S Adenosyl-L-Methionine (SAMe) As Antidepressant: Meta-Analy-sis of Clinical Studies' Acta Neurologica Scandinavica Supplement (1994): 154: 7-14.

48. Brodie HKH, Sack R, Siever L. Clinical studies of L-5-hydroxytryptophan in depression. In: Barchas J, Usdin E, eds. Serotonin and Behavior. New York: Academic Press; 1973:549-559.

49. Bruera E, Strasser F, Palmer JL, et al. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. J Clin Oncol. 2003;21:129–134.

50. Bruinsma KA, Taren DL. Dieting, essential fatty acid intake, and depression. Nutrition Rev. 2000;58(4):98-108.

51. Buajordet I, et al. Statins—the pattern of adverse effects with emphasis on mental reactions. Data from a national and an international database. Tidsskr Nor Laegeforen 1997;117:3210-3213.

52. Bucher HC, Hengstler P, Schindler C, et al. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med. 2002;112:298-304.

53. Buck AC, Jenkins A, Lingam K, et al. The treatment of idiopathic recurrent urolithiasis with fish oil (EPA) and evening primrose oil (GLA)—a double blind study. J Urol. 1993;149:253A.

54. Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet. 1989;2:757–761.

55. Byerley WF, et al. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. J Clin Psychopharmacol. 1987;7:127–137.

56. C. Cangiano, et al. Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated with 5-Hydroxytryptophan. Am J Clin Nutr 1992; 56: 863-7.

57. C. Maurizi. The Therapeutic Potential for Tryptophan and Melatonin: Possible Roles in Depression, Sleep, Alzheimer's Disease and Abnormal Aging. Med Hypoth. 1990; 31: 233-42.

58. Calabrese, Joseph R., et al.  Fish oils and bipolar disorder. Archives of General Psychiatry, Vol. 56, May 1999, pp. 413-14 (commentary)

59. Calderon-Guzman D, Hernandez-Islas JL, Espitia-Vazquez I, Barragan-Mejia G, Hernandez-Garcia E, Santamaria-del Angel D, Juarez-Olguin H. Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain. Arch Med Res 2004 Jul-Aug;35(4):271-4.

60. Cangiano C Ceci F Cairella M Cascino A Del Ben M Laviano A Muscaritoli M Rossi Fanelli F, Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Adv-Exp-Med-Biol. 1991; 294: 591-3 1991 0065-2598.

61. Cangiano C Laviano A Del Ben M Preziosa I Angelico F Cascino A Rossi Fanelli F, Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int-J-Obes-Relat-Metab-Disord. 1998 Jul; 22(7): 648-54 1998 0307-0565.

62. Cangiano C, Ceci F, Cairella M, et al. Effects of 5-Hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Adv Exp Med Biol. 1991;294:591–593.

63. Cangiano C, et al. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord. 1998; 22:648–654.

64. Cangiano, C. Ceci, F. Cascino, A. Del Ben, M. Laviano, A. Muscaritoli, M. Antonucci, F. Rossi Fanelli, F, Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. American-journal-of-clinical-nutrition (USA). (Nov 1992). v. 56(5) p. 863-867. 1992 0002-9165.

65. Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Bio Psychiatry. 2005 Feb 15;57(4): 343-50.

66. Caruso I, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 1990;18:201-9.

67. Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V, Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 1990 May-Jun;18(3):201-9.

68. Cassidy F, Ahearn E, Carroll J. Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients. Am J Psychiatry 1999;156:1417-20.

69. Castot A, Bidault I, Bournerias I, et al. “Eosinophilia-myalgia” syndrome due to L-tryptophan containing products. Cooperative evaluation of French Regional Centers of Pharmacovigilance. Analysis of 24 cases. Therapie. 1991;46(5):355–365.

70. Cauffield JS, Forbes HJ. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Lippincotts Prim Care Pract. 1999; 3(3):290-304.

71. Ceci F, Cangiano C, Cairella M, Cascino A, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm. 1989;76:109–117.

72. Childs MT, King IB, Knopp RH. Divergent lipoprotein responses to fish oils with various ratios of eicosapentaenoic acid and docosahexaenoic acid. Am J Clin Nutr. 1990;52:632-639.

73. Chappell J. The Miracle Elements: Fossilized Stony Coral Minerals. 2001; Clark’s Printing Company, Inc. Ventura, CA

74. Chiu CC, Huang SY, Su KP, et al. Polyunsaturated fatty acid deficit in patients with bipolar disorder. Eur Neuropsychopharmacol 2003;13(2):99-103.

75. Christensen O, Christensen E. Fat consumption and schizophrenia.Acta Psychiatr Scand 1988;78(5):587-591

76. Clark WF, Parbtani A, Naylor CD, et al. Fish oil in lupus nephritis: clinical findings and methodological implications. Kidney Int. 1993;44:75–86.

77. Cleland L, James M, Proudman S. The role of fish oils in the treatment of rheumatoid arthritis. Drugs. 2003;63:845–853.

78. Cobiac L, Clifton PM, Abbey M, et al. Lipid, lipoprotein, and hemostatic effects of fish vs fish-oil n–3 fatty acids in mildly hyperlipidemic males. Am J Clin Nutr. 1991;53:1210–1216.

79. Coleman M. Myoclonus in the young after 5-hydroxytryptophan [letter]. N Engl J Med. 1977;296:820.

80. Conquer JA, Martin JB, Tummon I, et al. Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males. Lipids. 2000;35:149–154.

81. Cott J, Hibbeln JR. Lack of seasonal mood change in Icelanders. Am J Psychiatry 2001;158:328.

82. Cunnane SC, Ho SY, Dore-Duffy P, et al. Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. Am J Clin Nutr. 1989;50:801–806.

83. Curb JD, Reed DM. Fish consumption and mortality from coronary heart disease [letter]. N Engl J Med. 1985;313:821–822.

84. D. Murphy et al. Obssessive-Compulsive Disorder as a 5-HT Subsytem -Related Behavioral Disorder. Bri J Psychiatry. 1989; 155: 15-24.

85. D. Murphy et al. Obssessive-Compulsive Disorder as a 5-HT Subsytem -Related Behavioral Disorder. Bri J Psychiatry. 1989; 155: 15-24.

86. Dakshinamurti K, LeBlancq WD, Herchl R, Havlicek V. Nonparallel changes in brain monoamines of pyridoxine-deficient growing rats. Exp Brain Res 1976;26:355-66.

87. Dakshinamurti K, Sharma SK, Bonke D. Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats. Klin Wochenschr 1990;68:142-5.

88. Davidson MH, Maki KC, Kalkowski J, et al. Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. J Am Coll Nutr. 1997;16:236-243.

89. De Benedittis G, Massei R, Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo. J Neurosurg Sci 1985 Jul-Sep;29(3):239-48.

90. De Giorgis G, Miletto R, Iannuccelli M, Camuffo M, Scerni S, Headache in association with sleep disorders in children: a psychodiagnostic evaluation and controlled clinical study--L-5-HTP versus placebo. Drugs Exp Clin Res 1987;13(7):425-33. .

91. De Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994;343:1454–1459.

92. De Wilde MC, Farkas E, Gerritis M, Kiliaan AJ, Luiten PGM. The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion. Bran Res 2002; 947: 166-73.

93. Delgado PL, Price LH and others. Serotonin and the biology of depression. Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psych. 1994;51(11):865-74.

94. Delion S, Chalon S, Guilloteau D, et al. Alpha-linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotonergic neurotransmission in the rat frontal cortex. J Neurochem 1996;66(4):1582-91.

95. Deutch B, Jorgensen EB, Hansen JC. Menstrual discomfort in Danish women reduced by dietary supplements of omega-3 PUFA and B12 (fish oil or seal oil softgels). Nutr Res. 2000;20:621–631.

96. DeVane CL, Sallee FR. Serotonin selective reuptake inhibitors in child and adolescent psychopharmacology: A review of published experience. J Clin Psyc 1996;57:55-66.

97. Diabetes common in hospitalized bipolar patients. Reuters Health Sep 22 1999. http://www.reutershealth.com/frame_archive.html

98. Diamond S, Pepper BJ, Diamond MI, et al. Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports. Neurol. 1998;51(1):274-276.

99. DiGiacomo RA, Kremer JM, Shah DM. Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study. Am J Med. 1989;86:158–164.

100. Dolecek TA, Granditis G. Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). World Rev Nutr Diet. 1991;66:205–216.

101. Donadio JV Jr, Grande JP, Bergstralh EJ, et al. The long-term outcome of patients with IgA nephropathy treated with fish oil in a controlled trial. J Am Soc Nephrol. 1999;10:1772–1777.

102. Dry J, Vincent D. Effect of a fish oil diet on asthma: Results of a one-year double-blind study. Int Arch Allergy Immunol. 1991;95:156–157.

103. Durrington PN, Bhatnagar D, Mackness MI, et al. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart. 2001;85:544–548.

104. Dyerberg J. N-3 fatty acids and coronary artery disease: potentials and problems. Omega-3, Lipoproteins, and Atherosclerosis. 1996;27:251–258.

105. Edwards R, Peet M, Shay J, Horrobin D. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord. 1998;48(2-3):149-155.

106. Edwards, Rhian, et al. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. Journal of Affective Disorders, Vol. 48, 1998, pp. 149-55

107. Egede LE. Diabetes, major depression, and functional disability among U.S. adults. Diabetes Care 2004;27(2):421-8.

108. Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: a possible interaction. J Toxicol Clin Toxicol. 1998;36(3):195-203.

109. Ellis EF, Police RJ, Dodson LY, McKinney JS, Holt SA. Effect of dietary n-3 fatty acids on cerebral microcirculation. Am J Physiol 1992; 262: H1379-H1386.

110. Emsley R, Myburgh C, Oosthuizen P, Van Rensburg, SJ. Randomized, placebo-controlled study of ethyl-eicosapentaenoic acid as supplemental treatment in schizophrenia. Am J Psychiatry 2002;159(9):1596-8.

111. Endres S. Messengers and mediators: interactions among lipids, eicosanoids and cytokines. Am J Clin Nutr 1993;57(5 suppl):798S-800S.

112. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Diet and risk of dementia: does fat matter? The Rotterdam Study. Neurology 2002;59(12):1915-21.

113. FOOD AND DRUG ADMINISTRATION Talk Paper. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. 1998. Accessed at http://vm.cfsan.Food and Drug Administration.gov/~lrd/tp5htp.html on February 2, 2001.

114. Fenton WS, Dickerson F, Boronow J, et al. A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry 2001;158(12):2071-4.

115. Folia Psychiatr Neurol Jpn. 1978;32(2):223-30. PMID: 307522

116. Food & Drug Administration, Dear Colleague Letter: December 5, 1989 Update On L-Tryptophan, The FOOD AND DRUG ADMINISTRATION

117. Frangou S., Lewis M., McCrone P. Efficacy of Ethyl-Eicosapentaenoic Acid in Bipolar Depression: Randomised Double-Blind Placebo-Controlled Study. The British Journal of Psychiatry 2006; 188 (1): 46-50

118. Frangou, S. and Lewis, M. The Maudsley Bipolar Disorder Project a double-blind, randomized, placebo-controlled trial of ethyl-EPA as an adjunct treatment of depression in bipolar disorder. Bipolar Disorders 2002; 4 123. (abstract)

119. Fujiwara J, Otsuki S. Subtype of affective psychoses classified by response on amineprecursors and monoamine metabolism. J Oral Pathol 1973;2:93-100.

120. G. DeBenedittis and R. Massei. 5-HT Precursors in Migraine Prophy laxis: A Double-Blind Cross-Over Study with L-5-Hydroxytryptophan versus Placebo. Clin J Pain. 1986; 3: 123-29.

121. G. Huether, et al. The Metabolic Fate of Infused L-Tryptophan in Men: Possible Clinical Implications of the Accumulation of Circulating Tryptophan and Tryptophan Metabolites. Psychopharmacol (Germany). 1992; 109: 442-32.

122. Gaby. B6The Natural Healer. New Canaan: Keats: 1984.

123. Gallai V, Sarchielli P, Trequattrini A, et al. Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids. J Neuroimmunol. 1995;56:143–153.

124. Ganong WF. Review of Medical Physiology. 13th ed: Appleton & Lange; 1987.

125. Gardner DM, Lynd LD. Sumatriptan contraindications and the serotonin syndrome. Ann Pharmacother. 1998;32(1):33-38.

126. Geleijnse JM, Giltay EJ, Grobbee DE, et al. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens. 2002;20:1493-1499.

127. George TP, Godleski LS. Possible serotonin syndrome with trazodone addition to fluoxetine. Biol Psychiatry. 1996;39(5):384-385.

128. Gerbi A, Maixent JM, Ansaldi JL, et al. Fish oil supplementation prevents diabetes-induced nerve conduction velocity and neuroanatomical changes in rats. J Nutr. 1999;129:207–213.

129. Gijsman, H. J., J. M. van Gerven, M. L. de Kam, R. C. Schoemaker, M. S. Pieters, M. Weemaes, R. de Rijk, J. van Der Post and A. F. Cohen (2002). "Placebo-controlled comparison of three dose-regimens of 5- hydroxytryptophan challenge test in healthy volunteers." J Clin Psychopharmacol 22(2): 183-9.

130. Glueck CJ, McCarren T, Hitzemann R, et al. Amelioration of severe migraine with omega-3 fatty acids: a double-blind, placebo-controlled clinical trial [abstract]. Am J Clin Nutr. 1986;43:710.

131. Goldberg P, Fleming MC, Picard EH. Multiple sclerosis: decreased relapse rate through dietary supplementation with calcium, magnesium and vitamin D. Med Hypotheses. 1986;21:193–200.

132. Golden SH, Williams JE, Ford DE, Yeh, H-C, Sanford CP, Nieto FJ, Brancati, FL. Depressive symptoms and the risk of type 2 diabetes. Diabetes Care 2004;27(2):429-35.

133. Golomb BA. Cholesterol and violence: Is there a connection? Ann Intern Med 1998;128:478-487.

134. Greenfield SM, Green AT, Teare JP, et al. A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. Aliment Pharmacol Ther. 1993;7:159–166.

135. Guallar E, Hennekens CH, Sacks FM, et al. A prospective study of plasma fish oil levels and incidence of myocardial infarction in U.S. male physicians. J Am Coll Cardiol. 1995;25:387–394.

136. Gwaltney-Brant SM, Albretsen JC, Khan SA. 5-Hydroxytryptophan toxicosis in dogs: 21 cases (1989-1999). J Am Vet Med Assoc. 2000;216:1937-1940.

137. H. van Praag. Central Monoamine Metabolism in Depressions. I. Serotonin and Related Compounds. Compreh Psychiatry. 1980; 21: 30-43.

138. H. van Praag. Management of Depression with Serotonin Precursors. Biol Psychiatry. 1981; 16: 291-310.

139. H. van Praag. Studies of the Mechanism of Action of Serotonin Precursors in Depression. Psychopharmacol Bull. 1984; 20: 599-602.

140. Haag M. Essential fatty acids and the brain. Can J Psychiatry. 2003 Apr;48(3):195-203.

141. Hagan JJ, Hatcher JP, Slade PD. The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs. Eur J Pharmacol. 1995;294:743–751.

142. Haleem DJ, Yasmeen A and others. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life Sciences. 1995;57(19):PL285-92.

143. Halsted CH, Ghandi G, Tamura T. Sulfasalazine inhibits the absorption of folates in ulcerative colitis. N Engl J Med. 1981;305:1513–1517.

144. Halstead B. Fossil Stony Coral Minerals And Their Nutritional Application. 1999; Health Digest Publishing Company, Cannon Beach, Oregon

145. Hardman WE, Moyer MP, Cameron IL. Consumption of an omega-3 fatty acids product, INCELL AAFA, reduced side-effects of CPT-11 (irinotecan) in mice. Br J Cancer. 2002;86:983-988.

146. Harel Z, Biro FM, Kottenhahn RK, et al. Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents. Am J Obstet Gynecol. 1996;174:1335–1338.

147. Harris WS. Dietary fish oil and blood lipids. Curr Opin Lipidol. 1996;7:3–7.

148. Harris WS. N-3 fatty acids and lipoproteins: comparison of results from human and animal studies. Lipids. 1996;31:243–252.

149. Harrison BJ, Olver JS, Norman TR, Burrows, GD, Wesnes KA, Nathan PJ. Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. J Psychopharmacol 2004;18(1):32-40.

150. Hartvig P, Lindner KJ, Bjurling P, Langstrom B, Tedroff J. Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography. J Neural Trans 1995;102:91-7.

151. Hasbroucq T, Rihet P, Blin O, Possamal CA. Serotonin and human reaction processing: fluvoxamine can improve reaction time performance. Neurosci Lett 1997;229(3):204-8.

152. Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12-month randomised controlled trial. Gut. 1992;33:922–928.

153. HealthWell, 5-Hydroxytryptophan, HealthWell

154. Helander A, Wikstrom T and others. Urinary excretion of 5- hydroxyindole-3-acetic acid and hydroxytryptophol after oral loading with serotonin. Life Sciences. 1992;50(17):1207-13.

155. Helland IB, Smith L, Saarem K, et al. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003;111:E39–E44.

156. Hernandez AF, Montero MN, Pla A, Villanueva E, et al. Fatal moclobemide overdose or death caused by serotonin syndrome? J Forensic Sci. 1995;40(1):128-130.

157. Heron DS, Shinitzky M, Hershkowitz M, Samuel D. Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc Natl Acad Sci 1980; 77: 7463-67.

158. Hibbeln also published another study in May (J Affect Disord 2002 May;69(1-3):15-29) that showed that mothers selectively transfer DHA to their fetuses to support optimal neurological development during pregnancy. If they don't receive enough they run the risk of developing severe postpartum depression.

159. Hibbeln JR, et al. Are disturbances in lipid-protein interactions by phospholipase-A2 a predisposing factor in affective illness? Biol Psychiatry 1989;25:945-961.

160. Hibbeln JR, Salem N Jr. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr 1995;62(1):1-9.

161. Hibbeln JR. Fish consumption and major depression. Lancet 1998; 351: 1213.

162. Hibbeln JR. Seafood consumption, the DHA content of mothers milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord 2002; 69: 15-29.

163. Hibbeln, Joseph R. and Salem, Norman.  Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy.  American Journal of Clinical Nutrition, Vol. 62, July 1995, po. 1-98

164. Hillbrand M, et al. Investigating the role of lipids in mood, aggression, and schizophrenia. Psychiatr Serv 1997;48:875-876.

165.Hibbeln JR, et al. Do plasma polyunsaturates predict hostility and depression? World Rev Nutr Diet 1997;82:175-186.

166.Hibbeln JR, et al. Essential fatty acids predict metabolites of serotonin and dopamine in CSF among healthy controls, early and late onset alcoholics. Biol Psychiatry 1998;44:235-242.

167.Hibbeln JR, et al. A replication study of violent and non-violent subjects: CSF metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. Biol Psychiatry 1998;44:243-249.

168.Holman RT, et al. Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation. Proc Natl Acad Sci 1991;88:4835-4839.

169. Hornstra G, et al. Essential fatty acids in pregnancy and early human development. Eur J Obstet Gyn Reprod Biol 1995;61:57-62.

170. Hines Burnham T, et al, eds. Drug Facts and Comparisons 2000. 55th ed. St. Louis, MO: Facts and Comparisons; 2000.

171. Holt, S. The Antiporosis Plan. 2002; Wellnesspublishing, Newark, NJ

172. Holub BJ. Clinical Nutrition: 4. Omega-3 fatty acids in cardiovascular care. CMAJ 2002; 166: 608-15.

173. Horrobin DF, et al. Fatty acid levels in the brains of schizophrenics and normal controls. Biol Psychiatry 1991;30:795-805.

174. Horrobin DF. A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E). Prog Drug Res 2002;59:171-99.

175. Horrobin DF. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr Res 1998;30(3):193-208.

176. Horrobin, D. F. and Bennett, C. N. New gene targets related to schizophrenia and other psychiatric disorders: enzymes, binding proteins and transport proteins involved in phospholipid and fatty acid metabolism.Prostaglandins, Leukotrienes and Essential Fatty Acids 1999; 60: 141-167.

177. Horrobin, D. F. and Bennett, C. N. Depression and bipolar disorder: Relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, aging and osteoporosis: Possible candidate genes.
Prostaglandins Leukotrienes and Essential Fatty Acids 1999; 60: 217-234.

178. Horrobin, D. F., Jenkins, K., Bennett, C. N., and Christie, W. W.
Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding. Prostaglandins Leukotrienes and Essential Fatty Acids 2002; 66:83-90.

179. Hudson CJ, Young LT, Li PP, Warsh JJ. CNS signal transduction in the pathophysiology and pharmacology of affective disorders and schizophrenia. Synapse 1993;13(3):278-93.

180. Hyyppa MT, Jolma T, Liira J, Langvik VA, Kytomaki O. L-tryptophan treatment and the episodic secretion of pituitary hormones and cortisol. Psychoneuroendocrinology 1979;4:29-35.

181. Ishizuka T, Kajita K, Miura A, Ishizawa M, Kanoh Y, Itaya S, Kimura M, Muto N, Mune T, Morita H, Yasuda K. DHEA improves glucose uptake via activations of protein kinase C and phosphatidylinositol 3-kinase. Am J Physiol 1999 Jan;276(1 Pt 1):E196-204.

182. Iso H, Rexrode KM, Stampfer MJ, et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA. 2001;285:304–312.

183. Ito H, Kawashima R, Awata S, Ono S, et al. Hypoperfusion in the limbic system and prefrontal cortex in depression: SPECT with anatomic standardization technique. J Nucl Med 1996; 37: 410-4.

184. Ito J, Hosaki Y, Torigoe Y, Sakimoto K. Identification of substances formed by decomposition of peak E substance in tryptophan. Food Chem Toxicol. 1992;30(1):71–81.

185. J. Robertson and T. Monte. Natural Prozac-Learning to Release Your Body’s Own Anti-Depressants. San Francisco: Harper; 1997.

186. J. Wurtman. Carbohydrate Craving, Mood Changes and Obesity. J Clin Psychiatry. 1988; 49: 37-39.

187. Jacobs MN, Santillo D, Johnston PA, et al. Organochlorine residues in fish oil dietary supplements: comparison with industrial grade oils. Chemosphere. 1998;37:1709-1721.

188. James MJ, Cleland LG. Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum 1997;27:85-97.

189. Janicak PG, et al., Parenteral S-adenosylmethionine in depression: A literature review and preliminary report. Psychopharmacology Bulletin 25, 238-241, 1989.

190. Joffe RT, Sokolov ST. Co-administration of fluoxetine and sumatriptan: the Canadian experience. Acta Psychiatr Scand. 1997;95(6):551-552.

191. John H. Juhl, Fibromyalgia and the Serotonin Pathway, Alternative Medicine Review

192. Joly P, Lampert A, Thomine E, et al. Develoment of pseudobullous morphea and scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. J Am Acad Dermatol. 1991;25(2 pt 1):332–333.

193. Jouvet M, Albarede JL, Lubin S, Meyrignac C. Noradrenaline and cerebral aging. Encephale 1991 May-Jun;17(3):187-95.

194. Juhl JH, Fibromyalgia and the serotonin pathway. Altern Med Rev 1998 Oct;3(5):367-75.


195. K. Dakshinamurti, et al. Influence of B Vitamins on Binding Properties of Serotonin Receptors in CNS of Rats. Klin Wochenschr. 1990; 68: 142-45.


196. K. Tornebrandt, et al. Heart Involvement in Metastatic Carcinoid Disease. Clin Cardiol. 1986; 9 (1).

197. K. Zmilacher, et al. L-5-Hydroxytryptophan Alone and in Combination with a Peripheral Decarboxylase Inhibitor in the Treatment of Depression. Neuropsychobiology. 1988; 20: 28-35.

198. Kagan BL, et al., Oral S-adenosylmethionine in depression: A randomized, double-blind placebo-controlled trial. Am J Psychiatry 147, 591-595, 1990.

199. Kahn RS, Westenberg HG. L-5-hydroxytryptophan in the treatment of anxiety disorders. J Affect Disord. 1985 Mar-Apr;8(2):197-200.

200. Kahn RS, Westenberg HG, Verhoeven WM, et al. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo. Int Clin Psychopharmacol. 1987;2:33–45.

201. Kalmijn S, Launer LJ, Ott A, et al. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997;42(5):776-82.

202. Kaneko M, Kumashiro H, Takahashi Y, Hoshino Y. L-5HTP treatment and serum 5-HT level after L-5-HTP loading on depressed patients. Neuropsychobiology 1979;5:232-240.

203. Katzman MA et al. Central and peripheral chemoreflexes in panic disorder. Psychiatry Res 2002;113:181-92.

204. Keck PE Jr, McElroy SL, Freeman MP, et al. Randomized, placebo-controlled trial of eicosapentaenoic acid in bipolar depression. Bipolar Disord 2003;5(suppl 1):58.

204. Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United states. Arch Gen Psychiatry. 1994;51:8-19.

205. Kessing LV, Andersen PK. Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? J Neurol Neurosurg Psychiatry 2004;75: 1662-6.

206. Kimbrell TA, Ketter TA, George MS, Little JT, et al. Regional cerebral glucose utilization in patients with a range of severities in unipolar depression. Biol Psychiatry 2002; 51: 237-52.

207. Klarskov K, Johnson KL, Benson LM, Gleich GJ, Naylor S. Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. Adv Exp Med Biol. 1999;467:461-468.

208. Klerman GL, Weissman MM. Increasing rates of depression. JAMA 1989; 261: 2229-35.

209. Klerman GL. The current age of youthful melancholia. Evidence for incrase in depression among adolescents and young adults. Br J Psychiatry 1998; 152: 4-14.

210. Knekt P, Raitasalo R, Heliovaara M, et al. Elevated lung cancer risk among persons with depressed mood. Am J Epidemiol 1996;144:1096-103.

211. Kooy FH. Hyperglycaemia in mental disorders. Brain 1919; 42:214?89.

212. Kornstein SG, Schneider RK. Clinical features of treatment-resistant depression. J Clin Psychiatry. 2001;62 Suppl 16:18-25.

213. Kramer PD, Listening to Prozac. Viking Press, New York, NY 1993.

214. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2003;23(2):e20-e30.

215. Kromhout D, Bosschieter EB, De Lezenne Coulander C. The inverse relation between fish consumption and 20- year mortality from coronary heart disease. N Engl J Med. 1985;312:1205–1209.

216. Kroczka B, Brañski P, Pa³ucha A, Pilc A, Nowak G:Antidepressant-like properties of zinc in rodent forced swim test. Brain Res Bull, 2001, 55, 297–300

217. Kroczka B, Ziêba A, Dudek D, Pilc A, Nowak G: Zinc exhibits an antidepressant-like effect in the forced swimming test in mice. Pol J Pharmacol, 2002, 52, 403–406

218. Kromhout D, Feskens EJ, Bowles CH. The protective effect of a small amount of fish on coronary heart disease mortality in an elderly population. Int J Epidemiol. 1995;24:340–345.

219. Kruger MC, Coetzer H, de Winter R, et al. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Aging (Milano). 1998;10:385–394.

220. Kyle, D.J., et al. Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids, Vol. 34 (suppl), 1999, p. S245

221. L. Buydens-Branchey, et al. Age of Alcoholism Onset. II. Relationship to Susceptibility to Serotonin Precursor Availability. Arch Gen Psychiatry. 1989; 46: 231-36.

222. Lands, WE. Biochemistry and physiology of n-3 fatty acids. FASEB J. 1992 May;6(8):2530-6

223. Laugharne JD, et al. Fatty acids and schizophrenia. Lipids 1996;31(Suppl):S163-S165.

224. Leaf A, Jorgensen MB, Jacobs AK, et al. Do fish oils prevent restenosis after coronary angioplasty? Circulation. 1994;90:2248–2257.

225. Lee TH, Arm JP. Prospects for modifying the allergic response by fish oil diets. Clin Allergy. 1986;16:89–100.

226. Leigh-Firbank EC, Minihane AM, Minihane AM, et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. Br J Nutr. 2002;87:435-445.

227. Leonard BE. Serotonin receptors and their function in sleep, anxiety disorders and depression. [Review] Psychotherapy and psychosomatics. 1996;65(2):66-75.

228. Levine, Barbara S. Most frequently asked questions about DHA. Nutrition Today, Vol. 32, November/December 1997, pp. 248-49

229. Lewis CE. Timed excretion of 5-hydroxy-indoleactic acid after oral administration of bananas and 5-hydroxytrptamine. Proc Soc Exp Biol Med. 1958;99:523-5.

230. Lieb J, Karmali R, Horrobin D. Elevated levels of prostaglandin E2 and thromboxane B2 in depression. Prostaglandins Leukot Med 1983; 10: 361-7.

231. Lin EHB, Katon W, Von Korff M, Tang L, Williams JW Jr, Kroenke K, et al., for the IMPACT Investigators. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial. JAMA 2003;290(18):2428-34.

232. Linde K, et al, St John's wort for depression -- an overview and meta-analysis of randomized clinical trials. British Medical Journal 313(7052), 253-258,1996.

233. Livingston MG and Livingston HM. Monoamine oxidase inhibitors. An update on drug interactions. [Review] Drug Safety. 1996;14(4):219-27.

234. Llorente AM, Jensen CL, Voigt RG, et al. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. Am J Obstet Gynecol 2003;188(5):1348-53.

235. Loeschke K, Ueberschaer B, Pietsch A, et al.n-3 fatty acids only delay early relapse of ulcerative colitis in remission. Dig Dis Sci. 1996;41:2087–2094.

236. Logan AC. Neurobehavioral aspects of omega-3 fatty acids:possible mechanisms and therapeutic value in major depression. Altern Med Rev 2003;8:410-425.

237. Longo G, Rudoi I, Iannuccelli M, et al. Treatment of essential headache in developmental age with L-5-HTP (cross over double-blind study versus placebo) [in Italian; English abstract]. Pediatr Med Chir. 1984;6:241–246.

238. Lopez-Ibor Alino JJ, Ayuso Guiterrez JL, Montejo Iglesias ML. 5-Hydroxytryptophan (5-HTP) and a MAOI (Nialamide) in the treat of depressions. Int Pharmacopsychiat 1976;11:8-15.

239. Lorenz R, Weber PC, Szimnau P, et al. Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease—a randomized, placebo-controlled, double-blind cross-over trial. J Intern Med Suppl. 1989;225:225–232.

240. Lorenz-Meyer H, Bauer P, Nicolay C, et al. Omega-3 fatty acids and low carbohydrate diet for maintenance of remission in Crohn's disease. A randomized controlled multicenter trial. Study Group Members (German Crohn's Disease Study Group). Scand J Gastroenterol.1996;31:778–785.

241. Lundbaek JA, Andersen OS. Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers.
J Gen Physiol 1994;104(4):645-73.

242. Lungershausen YK, Abbey M, Nestel PJ, et al. Reduction of blood pressure and plasma triglycerides by omega-3 fatty acids in treated hypertensives. J Hypertens. 1994;12:1041–1045.

243. M. Jacobsen, et al. Cardiac Manifestations in Mid-gut Carcinoid Disease. Eur Heart J. 1995; 16: 263-68.

244. M. Werbach. Nutritional Influences on Illness, 2nd ed. ‘Atherosclerosis,’ 57-102. Tarzana, CA: Third Line Press; 1996.

245. Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY. Lowered n-3 polyunsaturated fatty acids in the serum phospholipids and cholesterol esters of depressed patients. Psychiatry Res 1999; 85: 275-291.

246. Maes M, Christophe A, Delanghe J, et al. Lowered omega-3 polyunsaturated fatty acids in serum phospholipids and cholesterol esters of depressed patients. Psychiatry Res 1999;85(3):275-91.

247. Maes M, et al. Fatty acid composition in major depression: Decreased omega-3 fractions in cholesteryl esters and increased C20:4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J Affect Disord 1996;38:35-46.

248. Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H; Fatty acid composition in major depression: decreased omega 3 fractions in cholesterol esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesterol esters and phospholipids., J Affect Disord o Volume 38 o Issue 1.

249. Maes M, Smith RS. Fatty acids, cytokines, and major depression. Biol Psychiatry 1998;43:313-14.

250. Maes M, D’Haese PC, Scharpe S, D’Hondt PD, Cosyns P, De Broe ME: Hypozincemia in depression J AffectDisord, 1994, 31, 135–140

251. Maggioni M, Picotti GB, Bondiolotti GP, Panerai A, Cenacchi T, Nobile P, Brambilla F. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand 1990; 81: 265-70.

252. Magnussen I, Nielson-Kudsk F. Bioavailability and related pharmacokinetics in man of orally administered L-5-hydroxytryptophan in steady state. Acta Pharmacol et Toxicol.

253. Mahadik SP, Evans DR. Essential fatty acids in the treatment of schizophrenia. Drugs Tod Mahadik SP, Mukherjee S. Free radical pathology and antioxidant defense in schizophrenia: A review. Schizophr Res 1996;19:1-17.

254. Mukerjee S, et al. Impaired antioxidant defense at the onset of psychosis. Schizophr Res 1996;19:19-26.

255. Mahadik SP, et al. Elevated plasma lipid peroxides at the onset of nonaffective psychosis. Biol Psychiatry 1998;43:674-679.ay 1997;33:5-17.

256. Mahadik SP, Scheffer RE. Oxidative injury and potential use of antioxidants in schizophrenia. Prostaglandins Leukot Essent Fatty Acids 1996;55: 45-54.

257. Maissen CP, Ludin HP. Comparison of the effect of 5-hydroxytryptophan and propranolol in the interval treatment of migraine [translated from German]. Schweiz Med Wochenschr. 1991;121:1585–1590.

258. Maksimov SV, Demchenko SV. Concentration of 17-ketosteroids (17-KS) and their fractions in the urine of males of different age with diabetes mellitus. Probl Endokrinol (Mosk) 1970 Nov-Dec;16(6):21-7.

259. Mamalakis G, Tornaritis M, Kafatos A. Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids 2002; 67: 311-18.

260. Mangoni AA, Sherwood RA, Swift CG, et al. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Intern Med. 2002;252:497–503.

261. Manku, M.S. and Horrobin, D.F.Phospholipids and fatty acid metabolism in schizophrenia and depressionNutrition and Biochemistry of Phospholipids.
Szuhaj, B.F. and van Nieuwenhuyzen, W. (Eds.), AOCS Press, Illinois 2003: 40-9.

262. Marangell LB, Martinez JM, Zboyan HA, et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160(5):996-8.

263. Marchioli R, Barzi F, Bomba E, Chieffo C, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time course analysis of the results of the Gruppo Italiano per lo studio della sopravvivenza nell’infarto myocardio (GISSI) -- prevenzione. Circulation 2002; 105: 1897-903.

264. Maron E, Toru I, Vasar V, Shlik J. The effect of 5-hydroxytryptophan on cholecystokinin-4-induced panic attacks in healthy volunteers. J Psychopharmacol 2004;18(2):194-9. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression (Cochrane Review). In: The Cochrane Library, Issue 4, 2001. Oxford: Update Software.

265. Martin RW, Duffy J, Engel AG, et al. The clinical spectrum of the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Clinical features in 20 patients and aspects of pathophysiology. Ann Intern Med. 1990;113:124–134.

266. Martin TG. Serotonin syndrome. Ann Emerg Med. 1996;28:520–526.

267. Mason BJ, Blackburn KH. Possible serotonin syndrome associated with tramadol and sertraline coadministration. Ann Pharmacother. 1997;31(2):175-177.

268. Matrenza C, Hughes J-M, Kemp AH, Wesnes KA, Harrison BJ, Nathan PJ. Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory. J Psychopharmacol 2004;18(1):21-31.

269. Matussek N, Angst J, Benkert O, et al. The effect of L-5-hydroxytryptophan alone and in combination with a decarboxylase inhibitor (Ro-4-4602) in depressive patients. Adv Biochem Psychopharmacol 1974;11:399-404.

270. Maurizi CP, “The therapeutic potential for tryptophan and melatonin” Med Hypoth 1990; 31:233-42.

271. Mayeno AN, Lin F, Foote CS, et al. Characterization of “peak E,” a novel amino acid associated with eosinophilia-myalgia syndrome. Science. 1990;250:1707–8.

272. McCowan PK, Quastel JH. Blood-sugar studies in abnormal mental states. J Ment Sci 1931; 77:525-48.

273. McGrath-Hanna NK, Greene DM, Tavernier RJ, Bult-Ito A. Diet and mental health status in the Arctic: is diet an important risk factor for mental health in circumpolar peoples? Int J Circumpolar Health 2003;62:228-41.

274. McKinney B and Crawford MA. Fibrosis in guinea pig hearts produced by plantain diet. Lancet. 1965;2(7418):880-2.

275. McKinney B. Studies on the experimental production of endomyocardial fibrosis and cardiomegaly of unknown origin by dietary means. American Heart Journal. 1975;90(2):206-14.

276. McLoughlin IJ, Hodge SJ: Zinc in depressive disorder.Acta Psychiatr Scand, 1990, 82, 451–453Nowak G, Szewczyk B: Mechanism contributing to anti-depressant zinc actions. Pol J Pharmacol, 2002, 54

277. McNeely W, Goa KL. Sibutramine. A review of its contribution to the management of obesity. Drugs 1998 Dec;56(6):1093-124., 587–592.

278. MedQuest, 5-HTP The Natural Antidepressant, Medical Horizons

279. Mellor JE, Laugharne JD, Peet M. Schizophrenic symptoms and dietary intake of n-3 fatty acids. Schizophr Res 1995;18(1):85-6.

280. Mendlewicz J, Youdim MB. Antidepressant potentiation of 5-hydroxytryptophan by L-depre-nil in affective illness. J Affect Disord 1980;2:137-146.

281. Menkes DB, Coates DC and Fawcett JP. Acute tryptophan depletion aggravates premenstrual syndrome. Journal of Affective Disorders. 1994;32(1):37-44.

282. Meyers S. Use of neurotransmitter precursors for treatment of depression. Alt Med Rev 2000;5(1):64-71.

283. Middleton SJ, Naylor S, Woolner J, et al. A double-blind, randomized, placebo-controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis. Aliment Pharmacol Ther. 2002;16:1131-1135.

284. Miller HEJ, Deakin JFW, Anderson IM. Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers. Brit J Psychiatry 2000;176:182-8.

285. Mitchell DC, et al. Why is docosahexaenoic acid essential for nervous system function? Biochem Soc Trans 1998;26:365-370.

286.Muldoon MF, et al. Lowering cholesterol concentrations and mortality: A quantitative review of primary prevention trials. BMJ 1990;301:309-314.

287. Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr 1987;26(8):406-11.

288. Mongeau R, Blier P, de Montigny C. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments. Brain Res Brain Res Rev 1997 Apr;23(3):145-95.

289. Montori VM, Farmer A, Wollan PC, et al. Fish oil supplementation in type 2 diabetes: a quantitative systematic review. Diabetes Care. 2000;23:1407–1415.

290. Mori TA, Bao DQ, Burke V, et al. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension. 1999;34:253–260.

291. Mori TA, Burke V, Puddey IB, et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr. 2000;71:1085-1094.

292. Morris MC, Evans DA, Bienias JL, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60(7):940-6.

293. Murphy FC, Smith KA, Cowen PJ, et al. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacol 2002;163:42-53.

294. Murray MT, Pizzorno JE. Bromelain. In: Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. Vol 1. 2nd ed. Edinburgh: Churchill Livingstone; 1999:783-794.

295. Murray CJL, Lopez AD: Global mortality, disability and the contribution of risk factors: global burden of diseasestudy. Lancet, 1997, 349, 1436–1442.

296. Murck H, Song C, Horrobin DF, Uhr M.Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression. International Journal of Neuropsychopharmacology 2004; 7 341-9.

297. Murray MT, Pizzorno JE. Encyclopedia of Natural Medicine. Prima Publishing; 1998.

298. Murray MT. 5-HTP, The Natural Way to Overcome Depression, Obesity, and Insomnia. Bantam Books, New York, 1998.

299. Murray, Michael, ND, Pizzorno, Joseph, ND, Encyclopedia of Natural Medicine, second ed. Prima Publishing, Rocklin. 1998.

300. Nagakura T, Matsuda S, Shichijyo K, et al. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur Respir J. 2000;16:861–865.

301. Nakajima T, Kudo Y, Kaneko Z. Clinical evaluation of 5-hydroxy-L-tryptophan as an antidepressant drug.

302. Naliwaiko K, Araujo RL, da Fonseca RV, Castilho JC, Andreatini R, Bellissimo MI, Oliveira BH, Martins EF, Curi R, Fernandes LC, Ferraz AC. Effects of fish oil on the central nervous system: a new potential antidepressant?. Nutr Neurosci, 2004 Apr; 7(2): 91-9.

303. Nardini, M., R. De Stefano, M. Iannuccelli, R. Borghesi and N. Battistini (1983). "Treatment of depression with L-5-hydroxytryptophan combined with chlorimipramine, a double-blind study." Int J Clin Pharmacol Res 3(4): 239-50.

304. Narrow WE. One year prevlance of depressive disorders among 18 and over in the U.S.: NIMH ECA prospective data. Population estimates based on U.S. Census estimated residential population age 18 and older on July 1, 1998. Unpublished.

305. Nathan PJ, Sitram G, Stough C, et al. Serotonin, noradrenaline and cognitive function: a preliminary investigation of the acute pharmacodynamic effects of a serotonin versus a serotonin and noradrenaline reuptake inhibitor. Behav Pharmacol 2000;11(7-8):639-42.

306. National Advisory Mental Health Council. Healthcare reform for Americans with severe mental illnesses. American Journal of Psychiatry. 1993; 150(10): 1447-65

307. Neaton JD, et al. Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med 1992;152:1490-1500.

308. Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002;159(3):477-9.

309. Nenseter MS, Osterud B, Larsen T, et al. Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. Nutr Metab Cardiovasc Dis. 2000;10:323–330.

310. Nenseter MS, Osterud B, Larsen T, et al. Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. Nutr Metab Cardiovasc Dis. 2000;10:323–330.

311. Nicolodi M, et. al., Fibromyalgia and migraine, two faces of the same mechanism, Adv Exp Med Biol. 1996;398:373-379.

312. Nightingale S, Woo E, Smith AD, et al. Red blood cell and adipose tissue fatty acids in mild inactive multiple sclerosis. Acta Neurol Scand. 1990;82:43–50.

313. Nilsen DW, Albrektsen G, Landmark K, et al. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr. 2001;74:50–56.

314. Nishino S, Ueno R, Ohishi K, Sakai T, Hayaishi O. Salivary prostaglandin concentrations: possible state indicators for major depression. Am J Psychiatry 1989; 146: 365-8.

315. Nisijima K, Shimizu M, Abe T, Ishijuro T. A case of serotonin syndrome induced by concomitant treatment with low-dose trazodone and amitriptyline and lithium. Int Clin Psychopharmacol. 1996;11(4):289-290.

316. Noaghiul S, Hibbeln JR. Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry, 2003 Dec;160(12):2222-7.

317. Norrish AE, Skeaff CM, Arribas GLB, et al. Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control study. Br J Cancer. 1999;81:1238–1242.

318. Nowak G, Szewczyk B, Wieroñska JM, Brañski P, Pa³ucha A, Pilc A, Sadlik K, Piekoszewski W:Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbec-tomy model in rats. Brain Res Bull, 2003, 61, 159–164.

319. Ohishi K, Ueno R, Nishino S, Sakai T, Hayaishi O. Increased level of salivary prostaglandins in patients with major depression. Biol Psychiatry 1988; 23: 326-34.

320. Olsen SF, Sorensen JD, Secher NJ, et al. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet. 1992;339:1003–1007.

321. Otto SJ, et al. Maternal and neonatal essential fatty acid status in phospholipids: An international comparative study. Eur J Clin Nutr 1997;51:232-242.

322. Ornstein R, Thompson R, The Amazing Brain. 1984; Houghton Mifflin Company, Boston, MA

333. Ouichou A, Zitouni M and others. Delta-sleep-inducing peptide stimulates melatonin, 5-methoxytryptophol and serotonin secretion from perifused rat pineal glands. Biol Signals. 1992;1(2):65-77.

334. Oxman TE, Barrett JE, Barrett J, Gerber P. Symptomatology of late-life minor depression among primary care patients. Psychosomatics 1990;31:174-80.

335. P. Hartvig et al. Pyridoxine Effect on Synthesis Rate of Serotonin in the Monkey Brain Measured with Positron Emission Tomography. J Neural Trans. 1995; 102: 91-7.

336. P. Turlapaty and B. Altura. Magnesium Deficiency Produces Spasms of Coronary Arteries: Relationship to Etiology of Sudden Death Ischemic Heart Disease. Science. 1980; 208: 198-200.

337.Panic disorder treatment and referral. National Institute of Mental Health, 1994. Pub. No. 94-3642. www.nimh.nih.gov/anxiety/pdtr.cfm.

338. Passi S, Cataudella S, Di Marco P, et al. Fatty acid composition and antioxidant levels in muscle tissue of different Mediterranean marine species of fish and shellfish. J Agric Food Chem 2002; 50(25):7314-22.

339. Paul Barney, Doctor's Guide to Natural Medicine, Woodland Publishing, 1998; p. 228, 270.

340. Peet M, Brind J, Ramchand CN, et al. Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr Res 2001;49(3):243-51.

341. Peet M, et al. Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients. J Psychiatr Res 1995;29:227-232.

342. Peet M, Horrobin DF, E-E Multicentre Study Group. A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms. J Psychiatr Res 2002;36(1):7-18.

343. Peet M, Horrobin DF, E-E Multicentre Study Group. A dose-ranging study of the effects of ethyl eicosapentaenoate in patients with ongoing depression in spite of apparently adequate treatment with standard drugs.Archives of General Psychiatry 2002, 59 913-9.

345. Peet M, Murphy B, Shay J, Horrobin D. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 1998; 43: 315-19.

346. Perry NK. Venlafaxine-induced serotonin syndrome with relapse following amitripyline. Postgrad Med J. 2000;76(894):254.

347. Physician's Desk Reference. 49th ed. Montvale, NJ: Medical Economics Data Production Company; 1995.

348. Picado C, Castillo JA, Schinca N, et al. Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. Thorax. 1988;43:93–97.

349. Pichard C, Sudre P, Karsegard V, et al. A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and omega-3 fatty acids in HIV-infected patients. Swiss HIV Cohort Study. AIDS. 1998;12:53–63.

350. Pierpaoli W and Regelson W. Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc Nat Acad Sci USA. 1994;91:787-91.

351. Poeldinger W et al “Functional dimensional approach to depression” Psychopathology 1991; 24:53-81.

352. Poldinger W, Calanchini B and Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology. 1991;24(2):53-81.

353. Pradalier A, Bakouche P, Baudesson G, et al. Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia. 2001;21:818-822.

355. Puri B. K., Counsell S. J., Richardson A. J., Horrobin D. F. Eicosapentaenoic acid in treatment-resistant depression. Archives of General Psychiatry 2002; 59 91-92.

356. Puri BK, Counsell SJ, Hamilton G, Richardson AJ, Horrobin DF. Eicosapentaenoic acid (EPA) in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. International Journal of Clinical Practice 2001; 55 560-3.

357. Puttini PS, Caruso I. Primary fibromyalgia and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res. 1992;20:182–189.

358. R. Arora and R. Warner. Do Indole Markers Predict Carcinoid Heart Disease? Chest. 1986; 90: 87-9.

359. R. Kahn and H. Westenberg. L-5-Hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord, 1985; 8: 197-200.

360. Radack K, Deck C, Huster G. The effects of low doses of n-3 fatty acid supplementation on blood pressure in hypertensive subjects. A randomized controlled trial. Arch Intern Med. 1991;151:1173–1180.

361. Rambjor GS, Walen AI, Windsor SL Eicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oil in humans. Lipids. 1996;31 Suppl:S45-49.

362. Ratnavel RC, Burrows NP and Pye RJ. Scleroderma and the carcinoid syndrome. Clin Exp Derm. 1994;19(1):83-5.

363. Reeves RR, Bullen JA. Serotonin syndrome produced by paroxetine and low-dose trazodone. Psychosom. 1995 Mar-Apr;36(2):159-160.

364. Reibring L, Agren H, Hartvig P, et al. Uptake and utilization of [beta-11c] 5-hydroxytryptophan (5-HTP) in human brain studied by positron emission tomography. Pyschiatry Research. 1992;45:215–225.

365. Ribeiro CAF. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache. 2000;40:451-456.

366. Richardson AJ, Puri BK. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:233–239.

367. Richardson, A.J., et al. Red cell and plasma fatty acid changes accompanying symptom remission in a patient with schizophrenia treated with eicosapentaenoic acid. European Neuropsychopharmacology, Vol. 10, 2000, pp. 189-93

368. Ringer TV, Hughes GS, Spillers CR, et al. Fish oil blunts the pain response to cold pressor testing in normal males [abstract]. J Am Coll Nutr. 1989;8:435.

369. Risch S and Nemeroff CB. Neurochemical alterations of serotonergic neuronal systems in depression. J Clin Psychiatry. 1992;53 Suppl:3-7.

370. Robertson J, Monte T. Natural Prozac, San Francisco, Harper 1997.

371. Roger J. Cadieux, Practical Management of Treatment-Resistant Depression, American Family Physician December 1998

372. Rotrosen J, Wolkin A. Phospholipid and prostaglandin hypothesis of schizophrenia. In: Psychopharmacology: The Third Generation of Progress. Meltzer HY, ed. New York: Raven Press; 1987:759-764.

373. Rudin DO. The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra. Biol Psychiatry 1981; 16: 837-850.

374. Rosa AO, Lin J, Calixto JB, Santos AR, Rodrigues AL: Involvement of NMDA receptors and L-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice. Behav Brain Res, 2003, 144, 87–93.

375. Rousseau, J. J. (1987). "Effects of a levo-5-hydroxytryptophan-dihydroergocristine combination on depression and neuropsychic performance: a double-blind placebo- controlled clinical trial in elderly patients." Clin Ther 9(3): 267-72.

376. Rudra PK, Krokan HE. Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. Anticancer Res. 2001;21(1A):29-38.

377. Ryan ND, Birmaher B. and others, Neuroendocrine response to L-5-hydroxytryptophan challenge in prepubertal major depression. Arch Gen Psych. 1992;49(11):843-51.

378. S Takahashi, et al. Effect of L-5-Hydroxytryptophan on Brain Monoamine Metabolism and Evaluation of Its Clinical Effect in Depressed Patients. Psychiat Res 1975; 12: 177-87.

379. S. Risch and C. Nemeroff. Neurochemical Alterations of Serotonergic Neuronal Systems in Depression. J Clin Psychiatry. 1992; 53: 3-7.

380. Sacks FM, Stone PH, Gibson CM, et al. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol. 1995;25:1492–1498.

381. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune krill oil on the management of premenstrual syndrome and dysmenorrheal. Altern Med Rev 2003;8:171-79.

382. Sandyk R “L-Tryptophan in neuro psychiatric disorders, a review” Int J Neuroscience 1992 67:124-144.

383. Sano I. Actas Luso Esp Neurol Psiquiatr 1973 Jan-Feb;1(1):223-31. PMID: 4541701 Psychopharmacologic treatment with (L-5-HTP), L-5 hydroxytryptophan in endogenous depressions

384. Sano I. L-5-hydroxytryptophan-(L-5-HTP) therapy. Folia Psychiatr Neurol Jpn 1972;26:7-17.

385. Santucci M, Cortelli P, Rossi PG, et al. L-5-Hydroxytryptophan versus placebo in childhood migraine prophylaxis: a double-blind crossover study. Cephalalgia. 1986;6:155–157.

386. Scevola D, Oberto L, Faggi A, et al. Fish oil in the treatment of wasting syndrome. Int Conf AIDS. 1996;11:122.

387. Schmitz PG, McCloud LK, Reikes ST, et al. Prophylaxis of hemodialysis graft thrombosis with fish oil: double-blind, randomized, prospective trial. J Am Soc Nephrol. 2002;13:184-190.

388. Schruers K, van Diest R, Overbeek T, Griez E. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res 2002;113:237-43.

389. Schulyer L, Gaby A, Austin S, Brown, D, Wright J, Duncan A, The Natural Pharmacy. 1999; Three Rivers Press, New York, NY

390. Sellmayer A, Witzgall H, Lorenz RL, et al. Effects of dietary fish oil on ventricular premature complexes. Am J Cardiol. 1995;76:974–977.

391. Severus, W. Emanuel, et al. Omega-3 fatty acids: the missing link? Archives of General Psychiatry, Vol. 56, April 1999, pp. 380-81 (letter to the editor)

392. Sezi CL. Effects of protein deficient cassava diet on Cercopithecus aethiops hearts and its possible role in the aetiology and pathogenesis of endomyocardial fibrosis in man. East African Med J. 1996;73(5Suppl):S11-16.

393. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression (Cochrane Review). In: The Cochrane Library, Issue 4, 2001. Oxford: Update Software.

394. Shea-Moore MM, Thomas DP and Mench JA. Decreases in aggression in tryptophan-supplemented broiler breeder males are not due to increases in blood niacin levels. Poultry Science. 1996;75(3):370-4.

395. Shekelle RB, Missell LV, Paul O, et al. Fish consumption and mortality from coronary heart disease [letter]. N Engl J Med. 1985;313:820–821.

396. Shekelle RB, Shryock AM, Paul O, et al. Diet, serum cholesterol, and death from coronary heart disease. The Western Electric Study. N Engl J Med. 1981;304:65–70.

397. Shibata H, Perusse F, Bukowiecki LJ. The role of insulin in nonshivering thermogenesis. Can J Physiol Pharmacol 1987 Feb;65(2):152-8.

398. Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease. 9th ed. Media, Pa: Williams & Wilkins; 1999.

399. Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:70-75.

400. Silvers KM, Scott KM. Fish consumption and self reported physical and mental health status. Public Health Nutr 2002; 5: 427-31.

401. Simopoulos AP, Leaf A, Salem N. Workshop on the essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. J Am Coll Nutr 1999; 18: 487-9.

402. Simopoulos AP. Evolutionary aspects of diet and essential fatty acids. World Rev Nutr Diet 2001; 88: 18-27.

403. Simopoulos AP. Overview of the evolutionary aspects of n-3 fatty acids in the diet. World Rev Nutr Diet 1998; 83: 1-11.

404. Singer P, Jaeger W, Wirth M, et al. Lipid and blood pressure-lowering effect of mackerel diet in man. Atherosclerosis. 1983;49:99–108.

405. Singer P, Melzer S, Goschel M, et al. Fish oil amplifies the effect of propranolol in mild essential hypertension. Hypertension. 1990;16:682–691.

406. Singh RB, Niaz MA, Sharma JP, et al. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4. Cardiovasc Drugs Ther. 1997;11:485-491.

407. Siow YL, Dakshinamurti K. Effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase in adult rat brain. Exp Brain Res 1985;59: 575-81.

408. Siscovick DS, Raghunathan TE, King I, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA. 1995;274:1363–1367.

409. Smuts CM, Huang M, Mundy D, et al. Plasse T, Major S, Carlson SE. A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. Obstet Gynecol. 2003;101:469–479.

410. Smythe, G.A., and Lazarus, L. Growth hormone regulation by melatonin and serotonin. Nature 1973;244:230-231.

411. Song, C., Li, X., Kang, Z., Kadotomi, Y. Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1beta-Induced Changes in Dopamine and Metabolites in Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion.

412. Song, C., Phillips, A. G., Leonard, B. E., and Horrobin, D. F. Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats. Molecular Psychiatry 2003; 9: 630-638.

413. Song, C., Li, X. W., Leonard, B. E., and Horrobin, D. F. Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. Journal of Lipid Research 2003; 44: 1984-1991.

414. Soyland E, Funk J, Rajka G, et al. Effect of dietary supplementation with very-long-chain n–3 fatty acids in patients with psoriasis. N Engl J Med. 1993;328:1812–1816.

415. Sperling RI, Benincaso AI, Knoell CT, et al. Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Invest 1993;91(2):651-60.

416. Spiller HA, Gorman SE, Villalobos D, et al. Prospective multicenter evaluation of tramadol exposure. J Toxicol Clin Toxicol. 1997;35(4):361-364.

417. Stachow A and others. 5-Hydroxytryptamine and tryptamine pathways in scleroderma. Brit J Derm. 1977;97:147-154.

418. Stenius-Aarniala B, Aro A, Hakulinen A, et al. Evening primrose oil and fish oil are ineffective as supplementary treatment of bronchial asthma. Ann Allergy.1989;62:534–547.

419. Stenson WF, Cort D, Rodgers J, et al. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med. 1992;116:609–614.

420. Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. New Eng J Med. 1980;303:782-787.

421. Steven Meyers, Use of Neurotransmitter Precursors for Treatment of Depression, Alternative Medicine Review

422. Stevens LJ, Zentall SS, Abate ML, et al. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav 1996;59(4-5):915-20.

423. Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995;62(4):761-8.

424. Stokes PE. The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression. [Review]. European Neuropsychopharmacology. 1995;5 Suppl.:77-82.

425. Stoll AL, et al.Omega-3 fatty acids and bipolar disorders: a review. Prostaglandin, Leucotriens and Ess Fatty Acids. 1999; 60:329-337.

426. Stoll AL, Locke CA, Marangell LB, Severus WE. Omega-3 fatty acids and bipolar disorder: a review. Prostaglandins Leukot Essent Fatty Acids 1999; 60: 329-37.

427. Stoll AL, Severus E, Freeman MP, Rueter S, et al. Omega-3 fatty acids in bipolar disorder. A preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999; 56: 407-12.

428. Stoll AL, Severus WE. Mood stabilizers: shared mechanisms of action at postsynaptic signal transduction and kindling processes.Harv Rev Psychiatry 1996;4(2):77-89.

429. Stoll, Andrew L., et al. Omega 3 fatty acids in bipolar disorder. Archives of General Psychiatry, Vol. 56, May 1999, pp. 407-12 and pp. 415-16 (commentary) Calabrese, Joseph R., et al. Fish oils and bipolar disorder. Archives of General Psychiatry, Vol. 56, May 1999, pp. 413-14 (commentary)

430. Stoll, Andrew L., The Omega-3 Connection. 2001; First Fireside Edition,, New York, NY

431. Su K-P, Huang S-Y, Chiu C-C, Shen WW. Omega-3 fatty acids in major depressive disorder: a preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13(4):267-71.

432. T. Li Kam Wa, et al. Blood and Urine 5-Hydroxytryptamine [Serotonin] Levels after Administration of Two 5-Hydroxytryptophan Precursors in Normal Man. Bri J Clin Pharmacol. 1995; 39:327-29.

433. Takahashi S, Kondo H, Kato N. Effect of L-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients. J Psychiatr Res 1975;12:177-187.

434. Tanskanen A, et al.Fish consumption and depressive symptoms in the general population in Finland. Psychiatric services. 2001; 52(4):529-31.

435. Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamaki H. Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry 2001; 58: 512-513.

436. Tanskanen, Antti, et al. Fish consumption, depression, and suicidality in a general population. Archives of General Psychiatry, Vol. 58, May 2001, pp. 512-13

437. The Natural Pharmacist 5-HTP (5-Hydroxytryptophan) Prima Communications, Inc., The Natural Pharmacist

438. Thien FC, Woods RK, Walters EH. Oily fish and asthma—a fishy story? Med J Aust. 1996;164:135–136.

439. Thomas N, Morris HA, Scopacasa F, Wishart JM, Need AG. Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men. Age Ageing 1999 Mar;28(2):217-20.

440. Thompson, Richard, The Brain A Neuroscience Primer. 1993; W. H. Freeman and Company

441. Tiemeier H, van Tuijl HR, Hofman A, et al. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam study. Am J Clin Nutr 2003;78:40-46.

442. Timothy C. Birdsall, N.D.Thorne Research Alternative Med. Rev. 1998; V3,N4: 271-2805-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor - Meta-Analysis of Clinical Trials

443. Titus F, Davalos A, Alom J, Codina A.Eur Neurol. 1986;25(5):327-9. PMID: 35365215 -Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial.

444. Tomer A, Kasey S, Connor WE, et al. Reduction of pain episodes and prothrombotic activity in sickle cell disease by dietary n-3 fatty acids. Thromb Haemost. 2001;85:966–974.

445. Toner LC, Tsambiras BM, Catalano G, et al. Central nervous system side effects associated with zolpidem treatment. Clin Neuropharmacol. 2000;23(1):54-58.

446. Toyo’oka T, Yamazaki T, Tanimoto T, et al. Characterization of contaminants in EMS-associated L-tryptophan samples by high-performance liquid chromatography. Chem Pharm Bull. (Tokyo) 1991;39:820–2.

447. Trucksess MW, Thomas FS, Page SW. High-performance liquid chromatographic determination of 1,1’-ethylidenebis(L-tryptophan) in L-tryptophan preparations. J Pharm Sci. 1994;83:720–722.

448. Trucksess MW. Separation and isolation of trace impurities in L-tryptophan by high-performance liquid chromatography. J Chromatogr. 1993;630(1–2):147–150.

449. V. Linnoila and M. Virkkunen. Aggression, Suicidality, and Serotonin. J Clin Psychiatry. 1992; 53: 46-51.

450. Vaddadi KS, Soosai E, Chiu E, et al. A randomised, placebo-controlled, double blind study of treatment of Huntington's disease with unsaturated fatty acids. Neuroreport. 2002;13:29-33.

451. Valcavi R, Zini M, Maestroni G, and Conti A. Melatonin stimulates growth hormone secretion through pathways other than the growth-hormone releasing hormone. Clinical Endocrinology 1993;39:193-199.

452. Van Dam M, Stalenhoef AF, Wittekoek J, et al. Efficacy of concentrated n-3 fatty acids in hypertriglyceridaemia: a comparison with gemfibrozil. Clin Drug Invest. 2001;21:175–181.

453. Van der Stelt et al. Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats. Psychopharmacology 172:137-44 (2004)

454. Van Hiele LJ. L-5-Hydroxytryptophan in depression: the first substitution therapy in psychiatry? The treatment of 99 out-patients with 'therapy-resistant' depressions. Neuropsychobiology 1980;6:230-240.

455. Van Praag H. Management of depression with serotonin precursors. Biol Psychiatry 1981;16:291-310.

456. Van Praag HM “In search of the action of anti-depressants: 5HTP, tyrosine mixtures in depression” Neuropharmacol 1983; 22:433-40.

457. Van Praag HM et al “Therapeutic indications for serotonin potentiating compounds, a hypothesis” Biol Psychiat 1987; 22:205-12.

458. Van Praag HM, Korf J, Dols LCW, Schut T. A pilot study of the predictive value of the probenecid test in the application of 5-hydroxytryptophan as an antidepressant. Psychopharmacologia 1972;25:14-21.

459. Van Praag HM, van den Burg W, Bos ER, Dols LC. Psychopharmacologia. 1974;38(3):267-9.PMID: 45474185-hydroxytryptophan in combination with clomipramine in "therapy-resistant" depressions

460. Van Praag HM. Central serotonin: Its relation to depression vulnerability and depression prophylaxis. In: Obiols J, Ballus C, Gonzalez Monclus E, Pujol J, eds. Biological Psychiatry Today. Amsterdam: Elsevier/North-Holland; 1979:485-498.

461. Van Praag HM. Precursors of serotonin, dopamine and norepinephrine in the treatment of depression. In: Lemberger L, Reidenberg MM, eds. Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics. Maryland: American Society for Pharmacology and Experimental Therapeutics; 1984:541.

462. Van Praag HM. Serotonin precursors in the treatment of depression. Adv Biochem Psychopharmacol 1982;34:259-86.

463. Van Woert MH, Rosenbaum D and others. Long-term therapy of monoclonus and other neurological disorders with L-5-hydroxytryptophan and carbadopa. N Engl J Med. 1977;296(2):70-75.

464. Voigt RG, Llorente AM, Jensen CL, et al. A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. J Pediatr 2001;139(2):189-96.

465. Volker D, Fitzgerald P, Major G, et al. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol. 2000;27:2343–2346.

466. Vollset SE, Heuch I, Bjelke E. Fish consumption and mortality from coronary heart disease [letter]. N Engl J Med. 1985;313:820–821.

467. Von Schacky C, Angerer P, Kothny W, et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1999;130:554–562.

468. Vorbach EU, Arnoldt KH, Hubner WD. Efficacy and tolerability of St. John's wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry 1997 Sep;30 Suppl 2:81-5.

469. W. Byerley, et al. 5-Hydroxytryptophan: A Review of Its Antidepressant Efficacy and Adverse Effects. J Clin Psychopharmacol 1987; 7: 127-37.

470. W. Poeldinger, et al. A Functional-Dimensional Approach to Depression: Serotonin Deficiency as a Target Syndrome in a Comparison of 5 -Hydroxytryptophan and Fluvoxamine. Psychopathology. 1991; 24: 53-81.

471. Walton AJE, Snaith ML, Locniskar M, et al. Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus. Ann Rheum Dis. 1991;50:463–466.

472. Wardlaw G, Contemporary Nutrition. 1994; Times Mirror Higher Education Group, Inc. USA

473. Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand. 1999;99:112–116.

474. Wassertheil-Smoller S, Shumaker S, Ockene J, Talavera GA, Greenland P, Cochrane B, Robbins J, Aragaki A, Dunbar-Jacob J. Depression and cardiovascular sequelae in postmenopausal women: the Women’s Health Initiative (WHI). Arch Int Med 2004;164:289-98.

475. Whelton PK, Kumanyika SK, Cook NR, et al. Efficacy of nonpharmacologic interventions in adults with high-normal blood pressure: Results from phase 1 of the Trials of Hypertension Prevention. Am J Clin Nutr. 1997; 65(suppl 2):S652–S660.

476. Willatts P, et al. Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet 1998;352:688-691.

477. Woodman RJ, Mori TA, Burke V, et al. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. Atherosclerosis. 2003;166:85–93.

478. Williamson BL, Benson LM, Tomlinson AJ, et al. On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome. Toxicol Lett. 1997;92:139–148.

479. Wolkowitz OM, Reus VI, Keebler A, Nelson N, Friedland M, Brizendine L, Roberts E. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry 1999 Apr;156(4):646-9.

480. Woods RK, Thien FC, Abramson MJ. Dietary marine fatty acids (fish oil) for asthma. Cochrane Database Syst Rev. 2000;4:1–12 +5 tables.

481. Wurtman RJ and Wurtman JJ. Brain serotonin, carbohydrate-craving obesity and depression. [Review] Obesity Research. 1995;3 Suppl. 4:477S-480S.

482. Y. Hoshino, et al. Serum Serotonin Levels of Normal Subjects in Physiological State and Stress Conditions. Jpn J Psychosom Med. 1979; 19: 283-93.

483. Young SN, Teff KL “Tryptophan availability, 5HTP synthesis and 5HT function” Prog Neuro Psychopharmacol and Biol Psychiat 1989; 13:373-79.

484. Yam D, et. al. The effect of omega-3 fatty acids on risk factors for cardiovascular diseases. Harefuah. 2001;140:1156-1158.

485. Yehuda S, Rabinovitz S, Mostofsky DI. Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time course analysis. Neurochem Res 1998; 23: 627-34.

486. Yehyda S, Rabinovitz S, Mostofsky DI. Essential fatty acids are mediators of brain biochemistry and cognitive functions. J Neurosci Res 1999; 56: 565-70.

487. Zanarini MC, Frankenburg FR. Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study. Am J Psychiatry 2003;160(1):167-9.

488. Zimmer L, Vancassel S, Cantagrel S, Breton, et al. The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids. Am J Clin Nutr 2002; 75: 662-7.

489. Ziylan ZY, Bernard GC, LeFamconnier JM, Durand GA, Bourre JM. Effect of dietary n-3 fatty acid deficiency on blood-to-brain transfer of sucrose, alpha-aminoisobutyrie acid and phenylalamine in the rat. Neurosci Lett 1992; 137: 9-13.

490. Zlatkina AR, Sidel'nikova MV, Borodulina OV, Dubova VG. Characteristics of the amino acid spectrum of blood serum in diabetes mellitus. Probl Endokrinol (Mosk) 1977 May-Jun;23(3):7-12.

491. Zmilacher K, et al. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression. Neuropsychobiology 1988;20:28-35.

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